High-altitude Pulmonary Hypertension: an Update on Disease Pathogenesis and Management
نویسندگان
چکیده
منابع مشابه
High-altitude Pulmonary Hypertension: an Update on Disease Pathogenesis and Management.
High-altitude pulmonary hypertension (HAPH) affects individuals residing at altitudes of 2,500 meters and higher. Numerous pathogenic variables play a role in disease inception and progression and include low oxygen concentration in inspired air, vasculopathy, and metabolic abnormalities. Since HAPH affects only some people living at high altitude genetic factors play a significant role in its ...
متن کاملHigh-altitude pulmonary hypertension.
High-altitude pulmonary hypertension (HAPH) is a specific disease affecting populations that live at high elevations. The prevalence of HAPH among those residing at high altitudes needs to be further defined. Whereas reduction in nitric oxide production may be one mechanism for the development of HAPH, the roles of endothelin-1 and prostaglandin I₂ pathways in the pathogenesis of HAPH deserve f...
متن کاملPULMONARY HYPERTENSION Phosphodiesterase type 5 and high altitude pulmonary hypertension
Background: This study explored phosphodiesterase type 5 (PDE5) inhibition as a strategy for treating high altitude pulmonary arterial hypertension (HAPH). Methods: 689 subjects (313 men) of mean (SD) age 44 (0.6) years living above 2500 m were screened for HAPH by medical examination and electrocardiography, and 188 (27%) met the criteria for right ventricular hypertrophy. 44 underwent cardiac...
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Diverticular disease is one of the most common conditions in the Western world and one of the most common findings identified at colonoscopy. Recently, there has been a significant paradigm shift in our understanding of diverticular disease and its management. The pathogenesis of diverticular disease is thought to be multifactorial and include both environmental and genetic factors in addition ...
متن کاملPathogenesis of high-altitude pulmonary oedema.
We have read with great interest the paper by WEST et al. [1], regarding the stress failure mechanism of pulmonary capillaries in the pathogenesis of high-altitude pulmonary oedema (HAPE), and would like to add some considerations. HACKETT et al. [2] described a high incidence of HAPE in subjects without the right pulmonary artery. Recently, we have reported a case of unilateral, left sided HAP...
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ژورنال
عنوان ژورنال: The Open Cardiovascular Medicine Journal
سال: 2016
ISSN: 1874-1924
DOI: 10.2174/1874192401610010019